Jim O’Neill was officially sworn in today as the new Deputy Secretary of Health and Human Services (HHS) by Secretary Robert F. Kennedy, Jr. O’Neill, a seasoned leader in health care, technology, and public policy, will assist in managing the sprawling federal agency, which oversees critical institutions like the FDA, CDC, NIH, and Medicare.
Secretary Kennedy praised O’Neill’s background, stating, “Jim’s expertise in Silicon Valley and government uniquely positions him to transform HHS into a hub of innovation. We’ll leverage AI, telemedicine, and other breakthroughs to improve medical care for all Americans. He will spearhead modernization efforts, ensuring transparency, scientific integrity, and patient-centered outcomes.”
O’Neill’s appointment signals a strong push toward modernizing U.S. health care, prioritizing evidence-based science, and expanding access to cutting-edge treatments.
“I’m honored to return to HHS,” O’Neill said. “Every American deserves better health, and under President Trump and Secretary Kennedy’s leadership, we will tackle chronic disease, support families, and make care more affordable. Together, we can rebuild a healthier America.”
A Track Record of Innovation
O’Neill previously served at HHS from 2002 to 2008, where he led major FDA reforms, strengthened food and drug safety laws, and helped establish the Administration for Strategic Preparedness and Response (ASPR).
After his government service, he became a managing director at Clarium Capital and later led the Thiel Foundation, where he funded tech-driven nonprofits and co-founded the Thiel Fellowship—a program that launched billion-dollar startups.
Most recently, as CEO of the SENS Research Foundation, O’Neill advanced regenerative medicine research, targeting diseases like Alzheimer’s, cancer, and heart failure. His work focused on immune system rejuvenation, eliminating aging cells, and repairing mitochondrial damage.
With his return to HHS, O’Neill is expected to accelerate the agency’s shift toward technology-driven, patient-first health care solutions.
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